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Bolbosemma Panculatum Extract
Structure-activity relationship of tubeimosides in anti-inflammatory,
antitumor, and antitumor-promoting effects.
Yu TX, Ma RD, Yu LJ.
Department of Biochemistry and Molecular Biology, Beijing Medical
University, Beijing 100083, China.
AIM: To study structure-activity relationship of tubeimosides
isolated from Bolbostemma paniculatum for their anti-inflammatory,
antitumor, and antitumor-promoting effects. METHODS: Tubeimosides I,
II, and III were isolated from tubers of Bolbostemma paniculatum
(Maxim) Franquet (Cucurbitaceae), a Chinese folk medicine,"Tubeimu",
and their anti-inflammatory, anti-tumor, anti-tumorigenic activities,
and acute toxicity were studied in vivo. RESULTS: Tubeimosides I, II,
and III are all natural analogues of oleanane type of triterpenoid
saponins from the same medicinal plant, and all show
anti-inflammatory, antitumor, and antitumor-promo ting effects.
However, the anti-inflammatory, anti-tumor, and anti-tumorigenic
activities of tubeimoside II are stronger than those of tubeimoside
I, and the acute toxicity of tubeimoside II is lower than that of
tubeimoside I; the anti-inflammatory, anti-tumor, and
anti-tumorigenic activities of tubeimoside III are stronger than
those of tubeimoside II, and the acute toxicity of tubeimoside III is
also stronger than that of tubeimoside II. CONCLUSION: C-16 hydroxyl
group of tubeimoside II plays an important role in enhancing
biological activity of tubeimoside II and in decreasing its toxicity.
The difference of chemical structure in B and/or C position between
tubeimosides III and II plays an important role in enhancing
biological activity and toxicity of tubeimoside III. Therefore
tubeimosidre II may be the most promising agent for cancer
chemoprevention and chemotherapy among tubeimosides I, II, and III.
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