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Broccoli Extract
Broccoli Extract Brassica oleracea Botrytis cymosa Sulforaphane
indole-3-carbinol
Broccoli Extract Brassica oleracea Botrytis cymosa Sulforaphane
indole-3-carbinol
Indole-3-carbinol (I3C) is a secondary metabolite found in
cruciferous vegetables such as broccoli, cauliflower, kale, cabbage
and brussels sprouts. A secondary metabolite is one not found
preformed in vegetables, but formed after an enzyme in the vegetable
(myrosinase) is exposed to a phytochemcial in the vegetable
(glucobrassicin). This can occur only when vegetable cells are
crushed or eaten, and is referred to as enzymatic hydrolysis.
I3C, thus formed, is then broken down in the presence of acid (as in
the acid environment of the stomach) to various by-products such as
diindolylmethane (DIM), which are then absorbed.
Why is this important? Because I3C has been shown to inhibit cancer
cells in animal cancer models of the mammary, liver, and lung.5-7 It
is currently being evaluated in human clinical trials as a potential
chemopreventive agent against breast and ovarian cancers.8
I3C appears to work by upregulating or modulating certain enzymes
that improve the detoxification of various potential
carcinogens¡ªalthough it appears to be the breakdown products that
have this effect rather than IC3 itself. Furthermore, it is not clear
that DIM is the only breakdown product of importance.9
Certainly DIM by itself has an effect, but these other products may
also be important for the overall cancer-inhibiting action. As most
of the research to date has focused on I3C, it seems prudent at this
time to use supplements containing I3C instead of DIM. Just make sure
you take it with meals and have sufficient acidifying capacity in
your stomach.
Ms.lily liu
Sales Manager
Organic Herb Inc.
Phone +86 731 4060828
Mobile +86 135 1747 5149
Fax +86 731 4023669
Email: lily@xxxxxxxxxxxxxxxx
Website: <http://www.organic-herb.com>
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